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Article

Transcriptional regulation of disease-relevant microglial activation programs

2025-10-13

Abstract excerpt

<h4>Summary</h4> Microglia, the brain’s innate immune cells, can adopt a wide variety of activation states relevant to health and disease. Dysregulation of microglial activation occurs in numerous brain disorders, and driving or inhibiting specific states could be therapeutic. To discover regulators of microglia activation states, we conducted CRISPR interference screens in iPSC-derived microglia for inhibitors a...

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Literature Corpus work
a40fccb8-7fca-51b4-945d-3739dd54ab34
DOI
10.1101/2025.10.12.681832
Open publication

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Transcriptional regulation of disease-relevant microglial activation programsDOI 10.1101/2025.10.12.681832
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