Back to search

Article

The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions

2023-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulated microglia activation, leading to neuroinflammation, is crucial in neurodegenerative disease development and progression. The initial M1/M2 dual activation classification for microglia is outdated. Even the ‘disease-associated microglia’ (DAM) phenotype, firstly described in mice, falls short in representing the diverse microglia phenotypes in pathology. In this study, we have constr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
73a79d4c-de85-5a37-908a-ba3740d8d429
DOI
10.1101/2023.08.01.550767
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsDOI 10.1101/2023.08.01.550767
The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity
A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brainSemantic proximity
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?Semantic proximity
Analyzing microglial phenotypes across neuropathologies: a practical guide.Semantic proximity
Unveiling microglial heterogeneity from single-cell transcriptomics in neurodegenerative diseasesSemantic proximity
A Meta-Analysis of Microglial Heterogeneity and Gene Coexpression Networks in Aging and NeurodegenerationSemantic proximity
Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and diseaseSemantic proximity
Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived MicrogliaSemantic proximity
Diversity of transcriptomic microglial phenotypes in aging and Alzheimer's disease.Semantic proximity
Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell TechnologiesSemantic proximity
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signaturesSemantic proximity
Human microglia show unique transcriptional changes in Alzheimer’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.