Article
Integrated QTL mapping and CRISPR screening in pooled iPSC-derived microglia reveals genetic drivers of neurodegenerative risk
2025-08-19
Abstract excerpt
Mounting evidence implicates microglia in neurodegeneration, but linking disease-associated genetic variants to target genes and cellular phenotypes is hindered by the inaccessibility of these cells. We differentiated 261 human iPSC lines into microglia-like cells (iMGL) in pools with phenotypic (differentiation, phagocytosis and migration) and single-cell transcriptomic readouts. Burden analysis of deleterious va...
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Identifiers and source
- Literature Corpus work
- d1767d4d-e134-5656-a4b5-1c5ec4fc357a
- DOI
- 10.1101/2025.08.18.670767