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An integrated toolkit for human microglia functional genomics

10 Apr 2024

Abstract excerpt

BACKGROUND: Microglia, the brain's resident immune cells, play vital roles in brain development, and disorders like Alzheimer's disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such as prolonged differentiation time, lack of detailed characterization, and limited gene function investigation via...

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PMID: 38600587
DOI: 10.1186/s13287-024-03700-9

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