Stress-Responsive Transcriptomic Signatures in Human iPSC-Derived Microglia Reveal Links to Alzheimer’s Disease Risk Genes

Abstract excerpt

Cellular stress responses are essential for maintaining homeostasis in the face of environmental or internal challenges. In the central nervous system, microglia serve as key stress sensors and immune responders, shaping neuroinflammatory processes and disease progression. However, the molecular programs engaged by distinct stressors and their impact on microglial viability remain incompletely understood. In this...

Topics

Open a Topic to create a Post that cites this publication.

• Alzheimer Disease
• Interferon-gamma
• Interferon Type I
• Macrophage Activation
• Macrophages
• Microglia
• Single-Cell Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

ea59f40f-7e5a-5112-84b6-5c780a644306

DOI

10.1101/2025.08.30.673269