Article

High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer’s disease

2025-03-11

Abstract excerpt

Genome-wide association studies (GWAS) have identified over a hundred genetic risk factors for Alzheimer’s disease (AD), many of which are predominantly expressed in microglia. However, the pathogenic role for most of them remains unclear. To systematically investigate how AD GWAS variants influence human microglial inflammatory responses, we conducted CRISPR inhibition (CRISPRi) screens targeting 119 AD GWAS hits...

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Literature Corpus work: a651ed5f-7b2a-568f-b5f5-07280c485180
DOI: 10.1101/2025.03.09.642133

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