Back to search

Article

Neuronal age drives β-sheet accumulation and, together with ApoE4, enhances synaptic Aβ localization in APP <sup>NL-F</sup> neurons

2026-01-12

Abstract excerpt

Amyloid-β (Aβ) accumulation and aggregation are defining features of Alzheimer’s disease (AD), but the earliest cellular events driving these processes remain poorly understood. Here, we investigate Aβ dynamics in primary neurons derived from APP NL-F knock-in mice, which express human APP and Aβ at endogenous (non-overexpressed) levels. Using correlative optical photothermal infrared (OPTIR) spectromicroscopy an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f4ed7d9c-b0ea-5aa2-acbf-84ea0aee8019
DOI
10.64898/2026.01.10.697647
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Neuronal age drives β-sheet accumulation and, together with ApoE4, enhances synaptic Aβ localization in APP <sup>NL-F</sup> neuronsDOI 10.64898/2026.01.10.697647
APP <sup>NL-F</sup> knock-in Alzheimer’s Disease model mice reveal etiological convergence of aging and amyloidosisSemantic proximity
Isotope Encoded Spatial Biology Identifies Amyloid Plaque-Age-Dependent Structural Maturation, Synaptic Loss, and Increased ToxicitySemantic proximity
APOE4–Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation a preclinical Alzheimer’s disease modelSemantic proximity
Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APPSemantic proximity
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal VulnerabilitySemantic proximity
Amyloid beta exacerbates Tau-seeded pathology and drives tangle formation in human neuronal xenograftsSemantic proximity
The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain.Semantic proximity
Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology.Semantic proximity
TNF⍺-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neuronsSemantic proximity
Amyloidogenic proteolysis of APP regulates glutamatergic presynaptic functionSemantic proximity
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's diseaseSemantic proximity
The in-tissue molecular architecture of β-amyloid in the mammalian brainSemantic proximity
Select a neighboring publication to make it the new centre.