Article

APOE4–Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation a preclinical Alzheimer’s disease model

2025-11-12

Abstract excerpt

Amyloid-β (Aβ) and APOE4 represent two of the strongest pathological and genetic risk factors for Alzheimer’s disease (AD), but how these co-pathogens interact during preclinical stages remains undefined. We addressed this question by developing a humanized knock-in model expressing physiological, endogenously regulated human Aβ and APOE4. Aged App NLF :APOE4 mice displayed incipient amyloidosis with subtle memor...

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Literature Corpus work: af02af05-53ed-5291-b8e5-cd16c655208d
DOI: 10.1101/2025.11.11.687887

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