Article

Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP

2017-05-09

Abstract excerpt

Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer’s disease (AD), and several theories have been advanced to explain the involvement of APP in AD. A leading hypothesis proposes that a small amphipathic fragment of APP, the amyloid β-protein (Aβ), self-associates to form soluble aggregates which impair synaptic and network activity. Here, we report on the plasticity-disrupting effec...

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Literature Corpus work: 27fd1647-a86c-519c-8f35-f6f803d1ec0f
DOI: 10.1101/135673

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