Isotope Encoded Spatial Biology Identifies Amyloid Plaque-Age-Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity

Abstract excerpt

<title>Abstract</title> <p>Understanding how amyloid beta (Aβ) plaques form and progress to neurotoxicity in Alzheimer’s disease remains a significant challenge. This study aims to elucidate the processes involved in Aβ plaque formation and maturation using a knock-in Aβ mouse model (AppNL- F/NL-F). By employing mass spectrometry imaging and stable isotope labeling, we timestamped Aβ plaques from their initial de...

Topics

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• Alzheimer Disease
• Behavior, Animal
• Disease Models, Animal
• Hippocampus
• Long-Term Potentiation
• Mice, Inbred C57BL
• RNA-Seq
• Synaptic Transmission

Identifiers and source

Literature Corpus work

43b922ba-720f-58a3-8fca-25019aa326e8

DOI

10.21203/rs.3.rs-5829037/v1