Article

The in-tissue molecular architecture of β-amyloid in the mammalian brain

2022-11-09

Abstract excerpt

<h4>ABSTRACT</h4> Amyloid plaques composed of extracellular focal deposition of Aβ fibrils are a hallmark of Alzheimer’s disease (AD). Cryo-EM structures of Aβ fibrils purified from human AD brain tissue post mortem have recently been determined. However, the molecular architecture of amyloid plaques in the context of fresh, unfixed mammalian brain tissue is unknown. Here, using cryogenic correlated light and ele...

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Literature Corpus work: 37c60151-ce54-5c1b-8cc0-834ed632e86e
DOI: 10.1101/2022.11.08.515609

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