Article
The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain.
Nature communications - 17 May 2023
Leistner Conny, Wilkinson Martin, Burgess Ailidh, Lovatt Charlie Alexander, Goodbody Stanley, Xu Yong, Deuchars Susan, Radford Sheena E, Ranson Neil A, Frank René A W
Abstract excerpt
Amyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer's disease (AD). However, the molecular architecture of amyloid plaques in the context of fresh mammalian brain tissue is unknown. Here, using cryogenic correlated light and electron tomography we report the in situ molecular architecture of Aβ fibrils in the AppNL-G-F familial AD mouse model containing the Arctic mutation and an atomic model of ex...
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