Article

TNF⍺-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neurons

2024-09-01

Abstract excerpt

<h4>Summary</h4> Alzheimer’s disease (AD) patients exhibit an increased load of Aβ aggregates in the brain parenchyma. The neurotoxic nature of these aggregates has been underscored by recent advances in therapies aimed at reducing their load. To make further progress towards the development of increasingly effective treatments, there is a still largely unmet need for reliable cell models that comprehensively rec...

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Literature Corpus work: a0a1dde6-95af-5070-9a87-f959b01366ba
DOI: 10.1101/2024.08.30.610594

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