Back to search

Article

Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability

2025-02-11

Abstract excerpt

<title>Abstract</title> <p>Neurodegenerative diseases are characterized by progressive neuronal loss, yet subtle degeneration remains difficult to detect, hindering advancements in early diagnosis and intervention strategies. Here, we present a 3D, whole-brain, single-neuron atlas that aligns and compares neurons at single-cell resolution, surpassing 2D spatial limitations to precisely detect heterogeneous neurod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
12bc5f5b-3993-5667-b647-adbf0e4012b9
DOI
10.21203/rs.3.rs-5827312/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal VulnerabilityDOI 10.21203/rs.3.rs-5827312/v1
Distinctive Whole-brain Cell Types Predict Tissue Damage Patterns in Thirteen Neurodegenerative ConditionsSemantic proximity
Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditionsSemantic proximity
Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived MicrogliaSemantic proximity
All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer’s diseaseSemantic proximity
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.Semantic proximity
Neuronal Distribution of Tau Pathology, Microglial Gene Expression Trajectories, and Resilience to Alzheimer diseaseSemantic proximity
Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus.Semantic proximity
Unmasking Early Microglial Remodeling in an Alzheimer’s Disease Mouse ModelSemantic proximity
The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity
The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity
Unveiling microglial heterogeneity from single-cell transcriptomics in neurodegenerative diseasesSemantic proximity
Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell statesSemantic proximity
Select a neighboring publication to make it the new centre.