Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

Abstract excerpt

<title>Abstract</title> <p>Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here, single-molecule imaging shows that all isoforms of apoE associate with Aβ in the early stage...

Topics

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• Alzheimer Disease
• Amyloid
• Amyloid beta-Peptides
• Apolipoprotein E4
• Apolipoproteins E
• Genetic Predisposition to Disease
• Plaque, Amyloid
• Risk Factors

Identifiers and source

Literature Corpus work

acec8195-8913-5a6d-9044-059fa4fd728d

DOI

10.21203/rs.3.rs-2208663/v1