Article

Amyloid beta exacerbates Tau-seeded pathology and drives tangle formation in human neuronal xenografts

2026-06-17

Abstract excerpt

<title>Abstract</title> <p> The pathological cascade of Alzheimer's disease (AD) begins decades before clinical symptoms, yet modelling this slow and progressive process in experimental systems has remained challenging. Current models largely depend on Tau mutations associated with primary Tauopathies and fail to reproduce AD-relevant neurofibrillary tangle formation, even when human Tau isoforms and amyloid pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89c8cee4-148e-5cc2-b8d0-7d33a340061e
DOI: 10.21203/rs.3.rs-9942622/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Amyloid beta exacerbates Tau-seeded pathology and drives tangle formation in human neuronal xenograftsDOI 10.21203/rs.3.rs-9942622/v1Read

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer’s tau pathology and uncover human-specific neuronal vulnerabilitySemantic proximity Read

Host Tau Genotype Specifically Regulates and Designs Tau Seeding and Spreading Following Intracerebral Injection of Identical Tau AD InoculumSemantic proximity Read

Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: NLFTau <sup>m/h</sup> , an improved mouse model of Alzheimer’s disease without mutations in <i>MAPT</i>Semantic proximity Read

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Semantic proximity Read

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.Semantic proximity Read

Amyloid‐induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue‐culture modelsSemantic proximity Read

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.Semantic proximity Read

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.Semantic proximity Read

Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic TargetsSemantic proximity Read

Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of TauopathySemantic proximity Read

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.Semantic proximity Read

Combining P301L and S320F tau variants produces a novel accelerated model of tauopathySemantic proximity Read