Article

Amyloidogenic proteolysis of APP regulates glutamatergic presynaptic function

2025-08-01

Abstract excerpt

Disease causing mutations of Alzheimer’s disease (AD) point to dysregulations of APP proteolysis. During asymptomatic and early stages of AD, brain recordings revealed hyperexcitation reverting into over-inhibition as dementia progresses. Here, we show that endogenous APP and its proteolytic product APP-CTFβ, the precursors of Aβ, accumulate preferentially at excitatory synapses. Using pharmacological treatments t...

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Literature Corpus work: 88085ec6-f733-519f-b5b2-b800b1a4eac1
DOI: 10.1101/2025.08.01.667924

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