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Article

Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology.

Journal of neuroinflammation - 6 Sept 2018

Rothman Sarah M, Tanis Keith Q, Gandhi Pallavi, Malkov Vladislav, Marcus Jacob, Pearson Michelle, Stevens Richard, Gilliland Jason, Ware Christopher, Mahadomrongkul Veeravan, O'Loughlin Elaine, Zeballos Gonzalo, Smith Roger, Howell Bonnie J, Klappenbach Joel, Kennedy Matthew, Mirescu Christian

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a chronic neurodegenerative disease with pathological hallmarks including the formation of extracellular aggregates of amyloid-beta (Aβ) known as plaques and intracellular tau tangles. Coincident with the formation of Aβ plaques is recruitment and activation of glial cells to the plaque forming a plaque niche. In addition to histological data showing the formation of the...

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Identifiers

PMID: 30189875
DOI: 10.1186/s12974-018-1265-7
PMCID: PMC6127905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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