Article

KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres

2022-09-28

Abstract excerpt

<h4>SUMMARY</h4> Aneuploidy, the presence of chromosome gains or losses, is a hallmark of cancer and congenital syndromes. Here, we describe KaryoCreate ( Karyo type CR ISPR E ngineered A neuploidy Te chnology), a system that enables generation of chromosome-specific aneuploidies by co-expression of a sgRNA targeting chromosome-specific CENPA-binding ɑ-satellite repeats together with dCas9 fused to a mutant...

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Literature Corpus work: f4de7bc6-ad49-5e71-9b2c-04c8c7e17185
DOI: 10.1101/2022.09.27.509580

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