Article

CRISPR-based editing strategies to rectify<i>EYA1</i>complex genomic rearrangement linked to haploinsufficiency

2023-11-15

Abstract excerpt

Pathogenic structure variations (SVs) and genomic rearrangements are associated with various types of cancer and rare genetic diseases. Recent studies have used Cas9 nuclease with paired guide RNAs (gRNAs) to generate targeted chromosomal rearrangements. Studies on Cas9-mediated translocations and inversions have mainly focused on producing fusion proteins that cause cancer, whereas research on precision genome ed...

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Literature Corpus work: 7093c244-e6f1-505c-82d0-7ee368f6d651
DOI: 10.1101/2023.11.14.23298277

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