Article

Systematic Chromosome Rearrangement Induced by CRISPR-Cas9 Reshapes the Genome and Transcriptome of Human Cells

2021-06-15

Abstract excerpt

Chromosome rearrangement plays important roles in development, carcinogenesis and evolution. However, its mechanism and subsequent effects are not fully understood. At present, large-scale chromosome rearrangement has been performed in the simple eukaryote, wine yeast, but the relative research in mammalian cells remains at the level of individual chromosome rearrangement due to technical limitations. In this stud...

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Literature Corpus work: 4abf51b4-2ab8-5967-9e76-9a01445dae46
DOI: 10.1101/2021.06.15.448470

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