Article
Oncogene-like addiction to aneuploidy in human cancers.
Science (New York, N.Y.) - 25 Aug 2023
Girish Vishruth, Lakhani Asad A, Thompson Sarah L, Scaduto Christine M, Brown Leanne M, Hagenson Ryan A, Sausville Erin L, Mendelson Brianna E, Kandikuppa Pranav K, Lukow Devon A, Yuan Monet Lou, Stevens Eric C, Lee Sophia N, Schukken Klaske M, Akalu Saron M, Vasudevan Anand, Zou Charles, Salovska Barbora, Li Wenxue, Smith Joan C, Taylor Alison M, Martienssen Robert A, Liu Yansheng, Sun Ruping, Sheltzer Jason M
Abstract excerpt
Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. Using ReDACT, we created a panel of isogenic cells that have or lack common aneuploidies, and we demonstrate that...
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