Article

Aneuploidy drives the acquisition of cancer-specific driver genes

2024-09-04

Abstract excerpt

<title>Abstract</title> <p>Chromosome instability is highly prevalent in cancer and drives large scale chromosomal imbalances, known as aneuploidies. However, how aneuploidy contributes to tumorigenesis remains difficult to study due to the vast numbers of genes affected. Here, we develop a CRISPR-Knock Out and Activation Linked Assay (CRISPR-KOALA), enabling high-throughput bidirectional genetic screens in immun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3841226-8428-50d6-a36a-97ae53ae1ebf
DOI: 10.21203/rs.3.rs-4941895/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aneuploidy drives the acquisition of cancer-specific driver genesDOI 10.21203/rs.3.rs-4941895/v1Read

Oncogene-like addiction to aneuploidy in human cancersSemantic proximity Read

Patterns of Aneuploidy and Signaling Consequences in CancerSemantic proximity Read

Oncogene-like addiction to aneuploidy in human cancers.Semantic proximity Read

Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-TaijiSemantic proximity Read

Genomic and Functional Approaches to Understanding Cancer AneuploidySemantic proximity Read

Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability.Semantic proximity Read

Transient genomic instability drives tumorigenesis through accelerated clonal evolutionSemantic proximity Read

CRISPR-enabled genetic screens identify synthetic lethal targets across frequently altered cancer driversSemantic proximity Read

Bilallelic germline mutations in <i>MAD1L1</i> induce a novel syndrome of aneuploidy with high tumor susceptibilitySemantic proximity Read

Integrating gene expression, mutation and copy number data to identify driver genes of recurrent chromosome-arm lossesSemantic proximity Read

PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer CellsSemantic proximity Read

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.Semantic proximity Read