Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-Taiji

Abstract excerpt

<h4>SUMMARY</h4> Aneuploidy, the gain or loss of chromosomes, is prevalent in both normal and disease conditions, however, experimental approaches to engineer and study aneuploidy remain limited, leaving its functional significance under-characterized. Here, we present CRISPR-Taiji (CRISPRt), an efficient method for inducing chromosome-specific mis-segregation and aneuploidy generation across all 24 human chromos...

Topics

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• Carcinogenesis
• Cell Cycle Proteins
• CRISPR-Cas Systems
• DNA Damage
• DNA Repair
• Mutation
• Phenotype
• Trisomy

Identifiers and source

Literature Corpus work

ac571f3f-6c60-5e40-b60c-c11fbf1a202d

DOI

10.1101/2025.04.25.650684