Article

<i>ZATELLITE:</i> a toolkit to visualize and manipulate human centromeres in live cells using synthetic zinc fingers

2026-08-05

Abstract excerpt

Changes in the number of chromosomes or their spatial organization within the nucleus have critical consequences for cell fate. Yet capturing the karyotype or three-dimensional architecture of chromatin in living cells remains limited by the difficulty in labeling endogenous loci non-invasively. The most widely used tools rely on dCas9, a bulky protein whose persistent DNA binding interferes with DNA and RNA metab...

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Literature Corpus work: a535da94-87a4-5bee-a469-776246f6480d
DOI: 10.64898/2026.08.04.742839

Open publication

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