Article
Inactivation of hCDC4 can cause chromosomal instability.
Nature - 4 Mar 2004
Rajagopalan Harith, Jallepalli Prasad V, Rago Carlo, Velculescu Victor E, Kinzler Kenneth W, Vogelstein Bert, Lengauer Christoph
Abstract excerpt
Aneuploidy, an abnormal chromosome number, has been recognized as a hallmark of human cancer for nearly a century; however, the mechanisms responsible for this abnormality have remained elusive. Here we report the identification of mutations in hCDC4 (also known as Fbw7 or Archipelago) in both human colorectal cancers and their precursor lesions. We show that genetic inactivation of hCDC4, by means of targeted...
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