Article

Differential effects of aneuploidy on growth and differentiation in human intestinal stem cells

2023-09-24

Abstract excerpt

<h4>Summary</h4> Aneuploidy, a near ubiquitous genetic feature of tumors, is a context-dependent driver of cancer evolution; however, the mechanistic basis of this role remains unclear. Here, by inducing heterogeneous aneuploidy in non-transformed human colon organoids (colonoids), we investigate how the effects of aneuploidy on cell growth and differentiation may promote malignant transformation. Single-cell RNA...

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Literature Corpus work: f2b4fc60-9765-56c7-b45d-7c6b9ce2a8fd
DOI: 10.1101/2023.09.23.559117

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