Article

Oncogene-like addiction to aneuploidy in human cancers

2023-01-10

Abstract excerpt

<h4>ABSTRACT</h4> Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. Using ReDACT, we created a panel of isogenic cells that have or lack common aneuploidies, and we de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 86939445-5cb7-5080-a586-955399dbf110
DOI: 10.1101/2023.01.09.523344

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oncogene-like addiction to aneuploidy in human cancersDOI 10.1101/2023.01.09.523344Read

Oncogene-like addiction to aneuploidy in human cancers.Semantic proximity Read

Patterns of Aneuploidy and Signaling Consequences in CancerSemantic proximity Read

Aneuploidy as a cancer vulnerabilitySemantic proximity Read

Single-chromosome aneuploidy commonly functions as a tumor suppressorSemantic proximity Read

Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancerSemantic proximity Read

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damageSemantic proximity Read

Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.Semantic proximity Read

Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer.Semantic proximity Read

Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-TaijiSemantic proximity Read

Aneuploidy in human cancer: new tools and perspectivesSemantic proximity Read

Cancer. Aneuploidy drives a mutator phenotype in cancer.Semantic proximity Read

PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer CellsSemantic proximity Read