Article

Inducing Specific Chromosome Mis-Segregation in Human Cells

2022-04-19

Abstract excerpt

Cancer cells display persistent underlying chromosomal instability that results in chromosome mis-segregation, the formation of micronuclei, and abnormal numbers of chromosomes (aneuploidy). These features are common to nearly all human cancers, with individual tumour types intriguingly exhibiting characteristic subsets of whole, and sub-chromosomal aneuploidies. To date, few methods to induce specific aneuploidie...

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Literature Corpus work: 1e6d4b37-2079-5a5e-aafc-3b842debaabc
DOI: 10.1101/2022.04.19.486691

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