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Article

CRISPR/Cas9-mediated targeted chromosome elimination.

Genome biology - 24 Nov 2017

Zuo Erwei, Huo Xiaona, Yao Xuan, Hu Xinde, Sun Yidi, Yin Jianhang, He Bingbing, Wang Xing, Shi Linyu, Ping Jie, Wei Yu, Ying Wenqin, Wei Wei, Liu Wenjia, Tang Cheng, Li Yixue, Hu Jiazhi, Yang Hui

Abstract excerpt

BACKGROUND: The CRISPR/Cas9 system has become an efficient gene editing method for generating cells carrying precise gene mutations, including the rearrangement and deletion of chromosomal segments. However, whether an entire chromosome could be eliminated by this technology is still unknown. RESULTS: Here we demonstrate the use of the CRISPR/Cas9 system to eliminate targeted chromosomes. Using either multiple...

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Identifiers

PMID: 29178945
DOI: 10.1186/s13059-017-1354-4
PMCID: PMC5701507

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