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Article

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods.

The CRISPR journal - 1 Dec 2019

Rayner Emily, Durin Mary-Anne, Thomas Rachael, Moralli Daniela, O'Cathail Sean M, Tomlinson Ian, Green Catherine M, Lewis Annabelle

Abstract excerpt

CRISPR-Cas9 has quickly become the method of choice for genome editing, with multiple publications describing technical advances and novel applications. It has been widely adopted as a tool for basic research and has significant translational and clinical potential. However, its usage has outpaced the establishment of essential and rigorous controls for unwanted off-target effects, manifested as small mutations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31742432
DOI: 10.1089/crispr.2019.0006
PMCID: PMC6919265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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