Article

A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants

2022-05-18

Abstract excerpt

<h4>Background</h4> Quantifying an individual’s risk for common diseases is an important goal of precision health. The polygenic risk score (PRS), which aggregates multiple risk alleles of candidate diseases, has emerged as a standard approach for identifying high-risk individuals. A variety of tools have been developed to implement PRS. However, benchmarks for comparatively evaluating the performance of these di...

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Literature Corpus work: f37b36da-702f-5160-aa46-1fd91a2ef811
DOI: 10.1101/2022.05.16.492056

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