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A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release.

PloS one - 1 Jan 2024

Thompson Deborah J, Wells Daniel, Selzam Saskia, Peneva Iliana, Moore Rachel, Sharp Kevin, Tarran William A, Beard Edward J, Riveros-Mckay Fernando, Giner-Delgado Carla, Palmer Duncan, Seth Priyanka, Harrison James, Futema Marta, McVean Gil, Plagnol Vincent, Donnelly Peter, Weale Michael E

Abstract excerpt

We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits that has been made available on the individuals in UKB, using a unified pipeline for PRS evaluation. We also release a benchmarking software tool to enable like-for-like performance evaluation for different PRSs for the same disease or trait. Extensive benchmarking shows the PRSs in the UKB...

Topics

Humans
Multifactorial Inheritance
United Kingdom
Genetic Predisposition to Disease
Biological Specimen Banks
Genome-Wide Association Study
Software
Algorithms
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Benchmarking

Genetic Risk Score

UK Biobank

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Open in PubMed Open full text

Identifiers

PMID: 39292644
DOI: 10.1371/journal.pone.0307270
PMCID: PMC11410272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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