Article

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease

2017-11-15

Abstract excerpt

Identification of individuals at increased genetic risk for a complex disorder such as coronary disease can facilitate treatments or enhanced screening strategies. A rare monogenic mutation associated with increased cholesterol is present in ~1:250 carriers and confers an up to 4-fold increase in coronary risk when compared with non-carriers. Although individual common polymorphisms have modest predictive capacity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9012828d-5cda-5b2c-bacc-a013a2bbfa9b
DOI: 10.1101/218388

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary diseaseDOI 10.1101/218388Read

Polygenic background modifies penetrance of monogenic variants conferring risk for coronary artery disease, breast cancer, or colorectal cancerSemantic proximity Read

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.Semantic proximity Read

A framework for integrated clinical risk assessment using population sequencing dataSemantic proximity Read

Polygenic Risk Scores: The Next Step for Improved Risk Stratification in Coronary Artery Disease?Semantic proximity Read

Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank.Semantic proximity Read

Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases.Semantic proximity Read

Monogenic and Polygenic Models of Coronary Artery Disease.Semantic proximity Read

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseasesSemantic proximity Read

Validation of genome-wide polygenic risk scores for coronary artery disease in French CanadiansSemantic proximity Read

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseasesSemantic proximity Read

Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.Semantic proximity Read

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.Semantic proximity Read