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Article

A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants.

Briefings in bioinformatics - 19 Jan 2023

Wang Chonghao, Zhang Jing, Veldsman Werner Pieter, Zhou Xin, Zhang Lu

Abstract excerpt

Quantifying an individual's risk for common diseases is an important goal of precision health. The polygenic risk score (PRS), which aggregates multiple risk alleles of candidate diseases, has emerged as a standard approach for identifying high-risk individuals. Although several studies have been performed to benchmark the PRS calculation tools and assess their potential to guide future clinical applications,...

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PMID: 36585786
DOI: 10.1093/bib/bbac552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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