Article

Optimizing and benchmarking polygenic risk scores with GWAS summary statistics

2022-10-27

Abstract excerpt

<h4>Background: </h4> Polygenic risk score (PRS) is a major research topic in human genetics. However, a significant gap exists between PRS methodology and applications in practice due to often unavailable individual-level data for various PRS tasks including model fine-tuning, benchmarking, and ensemble learning. Results We introduce an innovative statistical framework to optimize and benchmark PRS models using s...

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Literature Corpus work: 32acc37b-e915-5e5e-8de4-a435e35a07bc
DOI: 10.1101/2022.10.26.513833

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