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Article

Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction.

Communications biology - 13 Feb 2024

Jung Hyein, Jung Hae-Un, Baek Eun Ju, Kwon Shin Young, Kang Ji-One, Lim Ji Eun, Oh Bermseok

Abstract excerpt

Polygenic risk score (PRS) is useful for capturing an individual's genetic susceptibility. However, previous studies have not fully exploited the potential of the risk factor PRS (RFPRS) for disease prediction. We explored the potential of integrating disease-related RFPRSs with disease PRS to enhance disease prediction performance. We constructed 112 RFPRSs and analyzed the association of RFPRSs with diseases to...

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Identifiers

PMID: 38351177
DOI: 10.1038/s42003-024-05874-7
PMCID: PMC10864389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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