Article

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases

2023-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Polygenic risk scores (PRS) are an emerging tool to predict the clinical phenotypes and outcomes of individuals. Validation and transferability of existing PRS across independent datasets and diverse ancestries are limited, which hinders the practical utility and exacerbates health disparities. We propose PRSmix, a framework that evaluates and leverages the PRS corpus of a target trait to improve...

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Literature Corpus work: 672c1a97-9d2d-5c5b-86b0-0e7e00bef740
DOI: 10.1101/2023.02.21.23286110

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