Prediction of Polygenic Risks by Screening Thousands of Polygenic Scores

Abstract excerpt

<h4>Rationale</h4> A polygenic score (PGS) summarizes a person’s genetic information in a single number for a trait, and its utility in genomic medicine is well-recognized. Although PGS models have been generated for many traits, they are not broadly available for certain traits due to limited sample sizes in studies of infrequent outcomes. Often, prediction of these not well-studied traits ( e.g. , treatment/dr...

Topics

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• Attention Deficit Disorder with Hyperactivity
• Biological Specimen Banks
• Biostatistics
• Genome-Wide Association Study
• Multifactorial Inheritance
• Phenotype
• Polymorphism, Single Nucleotide
• Sample Size

Identifiers and source

Literature Corpus work

55736cb8-bae2-5b1c-8606-607df6e3955b

DOI

10.1101/2025.10.03.680330