Article
<i>PGSFusion</i> streamlines polygenic score construction and epidemiological applications in biobank-scale cohorts
2024-08-07
Abstract excerpt
<h4>Background</h4> The polygenic score (PGS) is an estimate of an individual’s genetic susceptibility to a specific complex trait and has been instrumental to the development of precision medicine. Clinically, the simplest form of PGS, which is calculated as a weighted sum of variant counts, has been widely applied to conduct disease risk classification. Unfortunately, despite the critical importance of PGS, the...
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Identifiers and source
- Literature Corpus work
- c9c117cb-f4c1-527d-b24c-d1c00faa0e7b
- DOI
- 10.1101/2024.08.05.606619