Article

Instability of high polygenic risk classification and mitigation by integrative scoring

2024-07-24

Abstract excerpt

Polygenic risk scores (PRS) continue to improve with novel methods and expanding genome-wide association studies. Healthcare and commercial laboratories are increasingly deploying PRS reports to patients, but it is unknown how the classification of high polygenic risk changes across individual PRS. Here, we assessed association and classification performance of cataloged PRS for three complex traits. We chronologi...

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Literature Corpus work: fb559bd2-65aa-5c46-a477-5a4722b450c2
DOI: 10.1101/2024.07.24.24310897

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