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Article

Polygenic Risk Scores in Human Disease.

Clinical chemistry - 3 Jan 2025

Maamari Dimitri J, Abou-Karam Roukoz, Fahed Akl C

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) are measures of genetic susceptibility to human health traits. With the advent of large data repositories combining genetic data and phenotypic information, PRS are providing valuable insights into the genetic architecture of complex diseases and are transforming the landscape of precision medicine. CONTENT: PRS have emerged as tools with clinical utility in human disease....

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Identifiers

PMID: 39749511
DOI: 10.1093/clinchem/hvae190
PMCID: PMC13332810

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