Article

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

2017-01-17

Abstract excerpt

<h4>Background</h4> Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4 + T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification of candidate disease genes. <h4>Results</h4> Within four hours, activation of CD4 + T cells invokes changes in histone modifications and enhancer RNA...

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Literature Corpus work: f32be7ce-2dab-5f84-b1d3-972f6430d6ff
DOI: 10.1101/100958

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