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Article

Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms.

Nature methods - 1 May 2015

del Rosario Ricardo Cruz-Herrera, Poschmann Jeremie, Rouam Sigrid Laure, Png Eileen, Khor Chiea Chuen, Hibberd Martin Lloyd, Prabhakar Shyam

Abstract excerpt

Most disease associations detected by genome-wide association studies (GWAS) lie outside coding genes, but very few have been mapped to causal regulatory variants. Here, we present a method for detecting regulatory quantitative trait loci (QTLs) that does not require genotyping or whole-genome sequencing. The method combines deep, long-read chromatin immunoprecipitation-sequencing (ChIP-seq) with a statistical...

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PMID: 25799442
DOI: 10.1038/nmeth.3326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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