Article

Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic loci

2023-09-18

Abstract excerpt

<title>Abstract</title> <p>In this study, we present the most extensive dataset of chromatin conformation with matching gene expression and chromatin accessibility from primary T cells to date. We use this data to enhance our understanding of the mechanisms by which GWAS variants impact gene regulation, revealing how genetic variation alters chromatin accessibility and structure in primary cells at an unprecedent...

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Literature Corpus work: d2c86452-94a6-5fc2-be9e-60d54d24868e
DOI: 10.21203/rs.3.rs-3256438/v1

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