Article

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elements

2023-05-08

Abstract excerpt

<title>Abstract</title> <p>Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with autoimmune disease, but the causal variants and their contribution to immune dysregulation remain largely unknown. We measured the dynamics of chromosome conformation, chromatin accessibility, and gene transcription across three phases of naive human CD4+ T cell activation and co-localized ac...

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Literature Corpus work: 2ea5f9a4-a345-5d0e-a994-71a66f5a67f7
DOI: 10.21203/rs.3.rs-2855977/v1

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