Article

Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases

2019-03-04

Abstract excerpt

Complex immune disease variants are enriched in active chromatin regions of T cells and macrophages. However, whether these variants function in specific cell states or stages of cell activation is unknown. We stimulated T cells and macrophages in the presence of thirteen different cytokine cocktails linked to immune diseases and profiled active enhancers and promoters together with regions of open chromatin. We o...

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Literature Corpus work: 24950170-eb37-5695-acb9-bb9556c5796a
DOI: 10.1101/566810

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