Article

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

2019-11-01

Abstract excerpt

Genome-wide association studies have identified genetic variation contributing to complex disease risk. However, assigning causal genes and mechanisms has been more challenging because disease-associated variants are often found in distal regulatory regions with cell-type specific behaviours. Here, we collect ATAC-seq, Hi-C, Capture Hi-C and nuclear RNA-seq data in stimulated CD4+ T-cells over 24 hours, to identif...

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Literature Corpus work: aad7fcf6-9da4-57ae-821f-5eac88602354
DOI: 10.1101/827923

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