Article
Genetic and epigenetic fine mapping of causal autoimmune disease variants.
Nature - 19 Feb 2015
Farh Kyle Kai-How, Marson Alexander, Zhu Jiang, Kleinewietfeld Markus, Housley William J, Beik Samantha, Shoresh Noam, Whitton Holly, Ryan Russell J H, Shishkin Alexander A, Hatan Meital, Carrasco-Alfonso Marlene J, Mayer Dita, Luckey C John, Patsopoulos Nikolaos A, De Jager Philip L, Kuchroo Vijay K, Epstein Charles B, Daly Mark J, Hafler David A, Bernstein Bradley E
Abstract excerpt
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate causal variants for 21 autoimmune diseases from genotyping data. We integrated these predictions with transcription and cis-regulatory element annotations, derived by mapping RNA and chromatin in...
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