Article
Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis.
Nature communications - 2 Sept 2020
Yang Jing, McGovern Amanda, Martin Paul, Duffus Kate, Ge Xiangyu, Zarrineh Peyman, Morris Andrew P, Adamson Antony, Fraser Peter, Rattray Magnus, Eyre Stephen
Abstract excerpt
Genome-wide association studies have identified genetic variation contributing to complex disease risk. However, assigning causal genes and mechanisms has been more challenging because disease-associated variants are often found in distal regulatory regions with cell-type specific behaviours. Here, we collect ATAC-seq, Hi-C, Capture Hi-C and nuclear RNA-seq data in stimulated CD4+ T cells over 24 h, to identify...
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